Endocrine Abstracts

This work aimed at gathering own data on adrenal response to low-dose Synacthen test, CRH test and about periferal metabolism of cortisol in autoimmune type 1 diabetics with onset in adults. Seventy diabetics were investigated; age 44±10 years (mean±S.D.), age at diagnosis 28.5±10 years, disease duration 15±8 years, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%. The study was approved by the Ethical Committee. Adrenal reserve was t...

Background: A high percentage of adult smokers try to quit, but most of these attempts fail. The ability to predict the success or failure of smoking cessation efforts will be useful for clinical practice. Stress response is regulated by two primary neuroendocrine systems. Salivary cortisol has been used as a marker for the hypothalamus-pituitary-adrenocortical axis and salivary α-amylase as a marker for the sympathetic adrenomedullary system.Method...

The aim of the study was to obtain the basic data about adrenomedullin after 1 μg ACTH stimulation.Adrenomedullin has direct effect on adrenal cortex secretion, therefore we studied the changes of its concentrations during ACTH stimulation in diabetic patients suspected of hypocorticalism.Thirty-two diabetics type 1 (DM1) were investigated; 16 with and 16 without autoimmune thyroditis (AIT); age 44±10 years (mean±<sm...

The majority of pregnancy steroids originate in the fetal zone of the fetal adrenal (FZ). The data in the literature indicates that placental CRH directly stimulates the FZ. Despite the substantial alterations in the placental CRH production in late pregnancy, the predictivity of CRH for an estimation of term is poor. To sidetrack the expensive determination of unstable CRH, it may be expediential to use the FZ steroids. However, even these substances may not be optimal for pr...

Background: Familial resemblance was shown for body composition and risk factors in several studies. In twin studies which are powerful tool to assess genetically mediated traits significant resemblance was found in twins reared apart. In pairs of monozygotic twins was found significant resemblance in response to positive and negative energy balance. Aim of the study was to evaluate relationship of anthropometric parameters of parents and socioeconomic characteristics of famil...

Introduction: 7-hydroxyl DHEA derivatives are labelled as natural anti-glucocorticoid and neuroprotective substances. Their impact on the production of cytokines, their activation of apoptosis, influence on the migration of macrophages to peripheral tissue, their possible effect on angiogenesis, effect on inflammatory mediators (arachidonic acid metabolites) and their role in the mechanism of oxidative stress have been described.Methods: In our study we ...

The aim of the study was to obtain data about peripheral metabolism of cortisol.We compared diabetics with low response (LR), and with normal response (NR) during low dose ACTH test, and a control group (C).Twelve diabetics were investigated; LR (n=6), NR (n=6), age 44±10 year (mean±S.D.), age at diagnosis of DM1 28.5±10 year, disease duration 15±8 year, BMI 24.5±2.7 kg/cm2...

Melatonin has a key role in circadian timing system. At present, many other functions of melatonin are known. It shows a remarkable functional versatility exhibiting antioxidant (direct free radical scavenging and indirect antioxidant activities), oncostatic, anti-aging, immunomodulatory properties and many other functions. In addition to pineal gland, gastrointestinal tract is the second biggest source of melatonin. Question remains whether changes in endogenous melatonin may...

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

A 64-year-old lady presented with weight gain, tiredness, palpitations and tremor. She had no goitre and no other extra thyroidal manifestations. Both TSH and thyroid peroxidase antibodies (>1300) were elevated and she was treated by her GP with Thyroxine 50 mcg daily. She felt a lot worse on this, so it was discontinued and a full thyroid hormone profile was checked (see Table 1) which prompted referral; to Endocrinology.Other pituitary hormone leve...